Ramananda suggested that we give up practicing the rules of varnasrama-dharma and take sannyasa. Acceptance of sannyasa means to renounce materialistic life, and in doing so one has to engage fully in the devotional service of Godhead. In support of this idea, Ramananda quoted the above sloka from the Srimad-Bhagavatam. He also supported his suggestion with another sloka from the Bhagavad-gita (18.66):
mam ekam saranam vraja
aham tvam sarva-papebhyo
moksayisyami ma sucah
Here, the Personality of Godhead desires that everyone give up all other religious considerations and engage wholly and solely in following Him exclusively. “I will protect you from all difficulties arising out of renouncing all other engagements. You have nothing to fear.”
Excerpted from Bhaktivedanta VedaBase 2011.