Advancement of material science in the field of medical surgery has made it possible to change the body of a human being from male to female or from female to male by surgical operation. The desire to change the body in this way is a kind of mundane lust. This lusty idea is a perverted reflection of the transcendental idea of changing the body as in the case of the srutis. The idea of changing the body from one form to another is quite possible even by way of the materialistic mind. Therefore, by spiritual development the possibility of changing the body for the better is even greater.
The conclusion of the above-mentioned spiritual perfection is described in the Srimad-Bhagavatam (10.9.21):
nayam sukhapo bhagavan
yatha bhaktimatam iha
“Sri Krsna, who is the son of Srimati Yasodadevi, is more easily available to persons engaged in spontaneous devotional service than to persons engaged in empiric philosophical speculations.”
One who therefore accepts the example set by the cowherd girls of Vraja and always meditates upon the transcendental pastimes of Sri Sri Radha-Krsna day and night while living in Vraja and serving Them there will ultimately obtain the body of a sakhi and directly serve Radha and Krsna.
[Excerpted from the Bhaktivedanta VedaBase 2011.1]